In the pharmaceutical world, particle size analysis has traditionally been the method of choice to “characterize” raw materials. Beginning with sieve analyses all the way to more current technologies like laser light scattering, this physical characterization measurement has been used to set incoming raw material specifications, help determine which excipients will be used in a formulation, and troubleshoot product performance issues such as dissolution. While particle size analysis is, without a doubt, an important piece of the puzzle, it is exactly that – a piece. Other measurements can provide essential and useful information as well and, when paired with other techniques, assist the pharmaceutical scientist to more fully characterize their Active Pharmaceutical Ingredients (API) and excipient materials. Among these techniques is the measurement of surface area. Continue reading →
The GAB (Guggenheim, Anderson, and de Boer) equation [1, 2, 3] is a widely referenced model that is often used for the characterization of pharmaceuticals, excipients, and food [4, 5, 6, 7]. Three excipients: lactose, gelatin, and talc were characterized in a single sorption instrument using krypton adsorption and BET modeling to determine the as-received surface area, water sorption, and then krypton sorption to determine the impact of water sorption on the BET surface area. Continue reading →
Micromeritics Instrument Corporation is proud to announce its national accreditation as a Post-Secondary Avocational/Professional Development Institution by the Accrediting Council for Continuing Education and Training (ACCET), an accrediting agency recognized by the United States Department of Education. Attendees of Micromeritics Learning Center courses can now earn nationally accredited Continuing Education Units (CEUs) for completion of instrument operator training. As a result of this prestigious recognition, Micromeritics Learning Center has relocated all its educational information and training to www.micro.edu . Continue reading →
The selection of data used for fitting BET surface area is often an easy process using the MicroActive software. A broad range of isotherm data is selected and then the BET fit may be further refined to yield the specific surface area of a material. The process for data selection and optimization has been fully automated using the BET surface area rules advocated by Professor Jean Rouquerol, CNRS Marseille, FR. Prof. Rouquerol recommends the following criteria: Continue reading →
MicroActive 2.0 and MicroActive for 3Flex include a powerful utility for including the pore size distribution from mercury porosimetry analyses with pore size distributions calculated from gas adsorption isotherms. This new import function allows users to rapidly view micro, meso, and macro pore size distributions in one easy to use application.
The Micromeritics 3Flex has the added capability to collect and display pressure & quantity adsorbed versus time measurements. Data are collected every half second. This application note is a tutorial on how to collect the data being transmitted over the Ethernet cable used for instrument communication using a client such as PuTTY or HyperTerminal. Also, it will be shown how the captured data can easily be handled using scripts created in languages such as Python.