Monthly Archives: May 2013

ASTM D32 Committee Meeting, April 16, 2013

Andrew D. D’Amico, part of the scientific services group specializing in characterization by physical and chemical adsorption, recently attended the spring 2013 meeting of the American Society for Testing and Materials (ASTM) catalyst committee (D32). For this meeting, Andrew prepared material for three topics of interest: static carbon monoxide (CO) chemisorption on supported platinum on alumina catalysts, dynamic carbon monoxide pulse chemisorption on supported platinum on alumina catalysts, and dynamic acid site characterization of zeolites by propylamines. Andrew also contributed to the discussion to keep and update the current standard of terminology relating to catalysts and catalysis (D3766).
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A simple method for combining pore size distributions calculated from gas adsorption isotherms with mercury intrusion porosimetry

MicroActive 2.0 and MicroActive for 3Flex include a powerful utility for including the pore size distribution from mercury porosimetry analyses with pore size distributions calculated from gas adsorption isotherms. This new import function allows users to rapidly view micro, meso, and macro pore size distributions in one easy to use application.

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Characterization of physically modified glass beads as potential model carriers in DPIs

Contributed by:

Sarah Zellnitza, *, Jakob Dominik Redlinger-Pohnq, Nora Anne Urbanetza

aResearch Center Pharmaceutical Engineering GmbH, Graz/Austria

Introduction

Dry Powder Inhalers (DPIs) are medical devices used for pulmonary drug delivery. The formulations used in DPIs typically consist of adhesive mixtures of the drug and a carrier. In order to reach the tiny airways of the deep lung the drug particles have to exhibit an aerodynamic diameter of 1 µm to 5 µm. Particles of this size are rather cohesive and show poor flow properties and thus poor dosing [1]. That is why carrier based formulations, where the drug is attached to the surface of coarser carrier particles (50 µm – 200 µm) of adequate flowability, have been invented.

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